Zekayi Kutlubay* and Özge Karakuş
Mesotherapy is a minimally invasive technique that consists of the intradermal injection of variable mixtures of natural plant extracts, homeopathic agents, pharmaceuticals, vitamins, enzymes, hormones and other bioactive substances in microscopic quantities. Mesotherapy was first described by Frenchman Dr. Michel Pistor in 1952. He first administered procaine intravenously to treat an asthmatic patient and found that the patient’s hear loss was treated. Then he started to experiment on intradermal injections of procaine for various indications and named the method as “mesotherapy” in 1976. The use of mesotherapy, whether scientifically proven or not, has been outspreading over 50 years [1,2,3]. The term mesotherapy means the treatment of the mesoderm, which is one of the three primary germ layers in the early embryo that develops into connective tissue, muscle and the circulatory system. Mesotherapy is used in the treatment of cellulite, local fat deposits - xanthelasma, lipoma, alopecia, rejuvenation - wrinkles, skin tightening, hyperpigmentation and melasma, body contouring and scar reduction.
Hair mesotherapy can also be called “mesoplasty” or “mesohair”.
It represents a variety of minimally invasive techniques in which medications are directly injected into the scalp in order to improve alopecia and hair growth. Mesotherapy acts on the epidermis, dermal connective tissue, the circulation, the immune system and the neurosensory system. This therapy is effective at some certain forms of alopecia. Acute diffuse alopecias such as telogen effluvium and stress alopecias androgenetic alopecias, alopecia areata are the forms that mesotherapy can be used with good results. It is not effective at hair shaft dystrophies or scarring alopecias.
In the hair mesotherapy, there is lack of mixture and application scheme whose effectiveness has been proved scientifically. Content of cocktails changes due to physician’s practice and experience [9,10,11].
The effects of treatments are to restore and increase local microcirculation, provide nutritional input, slow down the programmed process of follicular involution, stimulate the hair’s environment through needling and complement other treatments [4,12].
The chemicals that are claimed to stimulate hair growth and new hair production are buflomedil, minoxidil, finasteride, dutasteride, biotin, vitamins and organic silicium.
Hair mesotherapy is a non-surgical, relatively painless injection technique. Despite the fact that there is very little scientific evidence sustaining its widespread use, the field of hair mesotherapy have grown enormously in the past few years, becoming a common method in cosmetic medicine.
Its use in cosmetic medicine to eliminate hair loss is gaining in popularity. To ensure a satisfying cosmetic result, it is critical to use the correct cocktail and injection technique. No long term side effects have been seen in thousands of patients.