Alopecia May Be Effectively Treated With Platelet-Rich Plasma Injection
Subcutaneous injection of platelet-rich plasma (PRP) may be effective for treating alopecia, according to an experimental study published in the Journal of Cosmetic Dermatology.
Sophie Orliac, MD, from Université Paris Diderot, and colleagues assessed the potential of PRP subcutaneous injection to treat alopecia and to evaluate local toxicity in 12 hairless rats. Subcutaneous injection occurred in 4 quadrants using either PRP, platelet-poor plasma (PPP), physiological serum (PS), or no treatment.
The researchers found that hair density was significantly improved at day 28 and at month 6 for PRP vs PS and PPP .
There was significant histological improvement between day 28 and month 6 for PRP vs PPP and PS for vessels, collagen, and epithelium. There was no local toxicity.
"Our study suggests that subcutaneous PRP injections using controlled concentration of platelets and leukocytes improve hair growth," the authors write.
Orliac S, Serfaty JM, Perozziello A, Zurlinden O, Louedec L, Dalludière B. Efficacy of subcutaneous injection of platelet-rich plasma in alopecia: a clinical and histological pilot study on a rat model with a six-month long-term follow-up experience [published online November 11, 2017]. J Cosmet Dermatol. doi: 10.1111/jocd.12425