Face Biorevitalization With Polynucleotides

Sebastiano Accaputo
August 1, 2022

Today, patients' need for elasticity and hydration of the skin of the face is increasingly affirmed. More and more often the attention is turned to improving the quality of the skin rather than to the classic treatments such as botulinum and fillers. In this regard, polynucleotide-based treatments are among the best solutions to counteract skin laxity and rejuvenate the skin.

Polynucleotides-HPT (Highly purified technology) are products of natural origin derived from fish intended for human consumption, obtained through a technology with a high degree of purification and safety.

The Polynucleotides

  • They consist of deoxyribonucleotide polymers (DNA fractions)
  • They carry out a trophic and stimulating action on existing fibroblasts, increasing their vitality
  • They stimulate cell proliferation, increasing the number of new fibroblasts
  • hey increase the vitality of fibroblasts with a physiological stimulation of collagen
  • They favour the regeneration of damaged, atrophic and senescent tissues
  • They increase the synthesis of type I and type III collagen

Polynucleotide Priming is the basic treatment that allows the skin to restore its optimal conditions in a natural way and to enhance the aesthetic medical treatment.

Also important is the synergistic effect with other aesthetic procedures such as laser, radiofrequency, filler, peeling, needling and surgery.

The infiltration with polynucleotides gives elasticity, hydration and trophism to all skin types, regardless of age. The skin takes on a better quality with greater brightness and freshness, with a reduction of wrinkles and skin laxity.


They are indicated around 35-40 years depending on the state of skin aging and for skin with expression wrinkles. They do not cause allergic reactions, they rarely cause unwanted side effects, they are well tolerated by everyone and with the correct application they are real anti-wrinkle and beauty therapies.

Polynucleotides represent the future of dermocosmetic. They restart the functionality of the cells by increasing the endogenous production of substances essential to the well-being of the skin.

Their use and effectiveness have been validated by scientific papers including the one published in the Journal of Cosmetology and Dermatology, 2021 Mar. and available here.

The most common brands available to us today are Plinest and Nucleofill.